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  • Human GAPDH (His Tag) recombinant protein

Human GAPDH (His Tag) recombinant protein

Cat.#: 503070

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Product Information

  • Product Name
    Human GAPDH (His Tag) recombinant protein
  • Documents
  • Description
    Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.
  • Protein name
    Glyceraldehyde-3-phosphate dehydrogenase
  • Protein short names
    MGC88685; MGC102544; MGC105239; MGC103191; G3PD; CDABP0047; HEL-S-162EP; GAPD; MGC103190; MGC102546
  • Uniprot ID
    P04406
  • Gene Name
    GAPDH; GAPD; CDABP0047; OK/SW-cl.12
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human GAPDH (P04406) (Met 1-Glu 335) was expressed, with a polyhistidine tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human GAPDH comprises 346 amino acids and migrates as an approximately 38 kDa band in SDS-PAGE under reducing conditions as predicted.
  • Purity
    > 93 % as determined by SDS-PAGE
  • Validations

    Human GAPDH Protein (His Tag) SDS-PAGE

    Human GAPDH Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"