Mouse CD297 (Fc Tag) recombinant protein

Mouse CD297 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

ADP-ribosyltransferase 4 (Dombrock blood group), also known as Mono-ADP-ribosyltransferase 4(ART4), Dombrock blood group carrier molecule and CD297, is a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. ART4 could be detected on HEL cells and erythrocytes by FACS analysis while it was absent from activated monocytes, despite the presence of ART4 mRNA in these cells. ART is also known as the carrier of the Dombrock blood group alloantigens (Do) which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane.

Ecto-ADP-ribosyltransferase 4

MONO(ADP-RIBOSYL)TRANSFERASE 4; NAD(P)(+)--ARGININE ADP-RIBOSYLTRANSFERASE 4; CD297; DOK1; DO; MONO-ADP-RIBOSYLTRANSFERASE 4; ECTO-ADP-RIBOSYLTRANSFERASE 4; ARTC4; MONO(ADP-RIBOSYL)TRANSFERASE; 4432404K01RIK; ADP-RIBOSYLTRANSFERASE 4 (DO BLOOD GROUP); DOMBROCK BLOOD GROUP CARRIER MOLECULE

Q9CRA0

Art4

Human Cells

A DNA sequence encoding the mouse Art4 (NP_080915.1) (Met1-Lys263) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Mouse

The recombinant mouse Art4 /Fc is a disulfide-linked homodimer. The reduced monomer comprises 481 amino acids and has a predicted molecular mass of 53.7 kDa. The apparent molecular mass of the protein is approximately 70 Kda in SDS-PAGE under reducing conditions due to glycosylation.

> 91 % as determined by SDS-PAGE