Cynomolgus CD297 (His Tag) recombinant protein

Cynomolgus CD297 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

ADP-ribosyltransferase 4 (Dombrock blood group), also known as Mono-ADP-ribosyltransferase 4(ART4), Dombrock blood group carrier molecule and CD297, is a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. ART4 could be detected on HEL cells and erythrocytes by FACS analysis while it was absent from activated monocytes, despite the presence of ART4 mRNA in these cells. ART is also known as the carrier of the Dombrock blood group alloantigens (Do) which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane.

NAD(P)(+)--arginine ADP-ribosyltransferase

MONO-ADP-RIBOSYLTRANSFERASE 4; ECTO-ADP-RIBOSYLTRANSFERASE 4; ARTC4; CD297; DOK1; DO; MONO(ADP-RIBOSYL)TRANSFERASE 4; NAD(P)(+)--ARGININE ADP-RIBOSYLTRANSFERASE 4; ADP-RIBOSYLTRANSFERASE 4 (DO BLOOD GROUP); DOMBROCK BLOOD GROUP CARRIER MOLECULE; 4432404K01RIK; MONO(ADP-RIBOSYL)TRANSFERASE

G7PJY0

EGM_03032

Human Cells

A DNA sequence encoding the cynomolgus ART4 (G7PJY0) (Thr31-Lys300) was expressed with a polyhistidine tag at the C-terminus.

Cynomolgus

The recombinant cynomolgus ART4 comprises 250 amino acids and has a calculated molecular mass of 29.1 KDa. The apparent molecular mass of it is approximately 41-46 KDa in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE