CSK Mouse Monoclonal antibody. Positive IF detected in A431 cells. Positive WB detected in Jurkat cells. Observed molecular weight by Western-blot: 50 kDa
ELISA, WB, IF
Human; other species not tested.
C Src kinase antibody; c src tyrosine kinase antibody; CSK antibody; Protein tyrosine kinase CYL antibody; Tyrosine protein kinase CSK antibody
This antibody was obtained by immunization of CSK recombinant protein (Accession Number: BC106073). Purification method: Protein A purified.
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20℃. DO NOT ALIQUOT
Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:107179(CSK antibody) at dilution of 1:1000
Immunofluorescent analysis of A431 cells using Catalog No:107179(CSK Antibody) at dilution of 1:50 and Rhodamine-Goat anti-Mouse IgG
CSK(Tyrosine-protein kinase CSK) is also named as C-Src kinase, protein-tyrosine kinase CYL and belongs to the protein kinase superfamily. Csk is a non-receptor tyrosine kinase with a molecular mass of 50 kDa. It contains the SH3 and SH2 domains in its N-terminus and a kinase domain in its C-terminus. It negatively regulates the kinase activity of SFKs and plays an important role in physiological functions via signaling pathways for cell proliferation, differentiation, adhesion, and migration(PMID:23548896). Csk may play a role in tumor suppression by inhibiting the oncogenic activity of SFKs. Indeed, overexpression of Csk can inhibit tumor growth of human colon cancer cells(PMID:23139636). This protein can be autophosphorylated(PMID:11181701).
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