CNDP2 Polyclonal Antibody
Polyclonal antibody to CNDP2
CNDP2 antibody; CN2 antibody; CPGL antibody; HEL-S-13 antibody; HsT2298 antibody; PEPA antibody; carnosine dipeptidase 2 antibody
Antigen: A synthetic Peptide of human CNDP2
PBS with 0.02% sodium azide, pH7.3.
Store at 4℃. Avoid freeze / thaw cycles.
WB 1:500 - 1:1000
Western blot - CNDP2 Polyclonal Antibody
Western blot analysis of extracts of A2058 cells, using CNDP2 antibody .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.
Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation. Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis.
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