Anti-CNDP2 antibody

Cat.#: 106284


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Product Information

  • Product Name
    Anti-CNDP2 antibody
  • Documents
  • Description
    Rabbit monoclonal to CNDP2
  • Tested applications
  • Species reactivity
    Mouse CNDP2
    Has cross-reactivity in ELISA with Human CNDP2
  • Alternative names
    0610010E05Rik antibody; C76600 antibody; Cn2 antibody; CN2 antibody; Cndp2 antibody; CNDP2 antibody; CPGL antibody; Dip-2 antibody; FLJ10830 antibody; HsT2298 antibody; Pep1 antibody; Pep-1 antibody; PEPA antibody; CN2 antibody; CPGL antibody; PEPA antibody; HsT2298 antibody; HEL-S-13 antibody; Cn2 antibody; Pep1 antibody; Dip-2 antibody; Pep-1 antibody; C76600 antibody; 0610010E05Rik antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CNDP2 (rM CNDP2; NP_075638.2; Met1-Asn475).
  • Clonality
  • Formulation
    0.2 μm filtered solution in PBS with 5% trehalose
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    IHC-P: 1-10 μg/mL

  • Validations

    CNDP2 Antibody, Rabbit MAb, Immunohistochemistry

    CNDP2 Antibody, Rabbit MAb, Immunohistochemistry

    Immunochemical staining of mouse CNDP2 in mouse kidney with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to nephric tubule.

  • Background
    Mouse cytosolic non-specific dipeptidase, also known as CNDP dipeptidase 2, Glutamate carboxypeptidase-like protein 1, Peptidase A, CNDP2 and CN2, is a cytoplasm protein which belongs to the peptidase M20A family. CNDP2 / CPGL is a cytosolic enzyme that can hydrolyze carnosine to yield l-histidine and beta-alanine. CNDP2 / CPGL hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. It may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Isoform 1 of CNDP2 / CPGL is ubiquitously expressed with higher levels in kidney and liver (at protein level). Isoform 2 of CNDP2 / CPGL is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. CNDP2 / CPGL is highly expressed in the histaminergic neurons in the tuberomammillary nucleus, implying that it may supply histidine to histaminergic neurons for histamine synthesis.
  • References
    • Bakker,SJ. et al., 2008, Diabetes  57 (12):e16; author reply e17. 
    • Wanic, K. et al., 2008, Diabetes  57 (9): 2547-51.
    • McDonough,CW. et al., 2009, Hum Genet 126 (2): 265-75.
    • Kaur,H. et al., 2009, J Biol Chem. 284 (21):14493-502.