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  • Mouse B7-H3/CD276 (His Tag) recombinant protein

Mouse B7-H3/CD276 (His Tag) recombinant protein

Cat.#: 500031

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Product Information

  • Product Name
    Mouse B7-H3/CD276 (His Tag) recombinant protein
  • Documents
  • Description
    B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to either promote or inhibit T-cell responses in various experimental systems. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is a novel protein structurally related to the B7 family of ligands by the presence of a single set of immunoglobulin-V-like and immunoglobulin-C-like (VC) domains. Previous studies have correlated its overexpression with poor prognosis and decreased tumor-infiltrating lymphocytes in various carcinomas including uterine endometrioid carcinomas, and mounting evidence supports an immuno-inhibitory role in ovarian cancer prognosis. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity.
  • Protein name
    CD276 antigen
  • Protein short names
    6030411F23RIK; 4IG-B7-H3; B7RP-2; AU016588; B7-H3; B7H3; CD276; PSEC0249
  • Uniprot ID
    Q8VE98
  • Gene Name
    Cd276
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse CD276 (NP_598744.1) (Met1-Phe244) was expressed with a C-terminal polyhistidine tag. The purified protein was biotinylated in vitro.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse CD276 comprises 227 amino acids and has a predicted molecular mass of 24.9 kDa. The apparent molecular mass of the protein is approximately 40.9 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 97 % as determined by SDS-PAGE
  • Validations

    Mouse CD276 / B7-H3 Protein (His Tag), Biotinylated

    Mouse CD276 / B7-H3 Protein (His Tag), Biotinylated

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"