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Product Name
Human CD276/B7H3/PSEC0249/UNQ309/PRO352 (His tag) recombinant protein
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Description
CD276, also known as B7-H3, is a member of the B7 superfamily with signature IgV and IgG regions in extracellular domains. It is a type I transmembrane protein and shares 20–27% amino acid identity with other B7 family members. B7-H3 is involved in the activation of T lymphocytes, and regulates murine bone formation. It is also reported that B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is expressed on T-cells, natural killer cells, and antigen presenting cells, as well as some non-immune cells, such as osteoblasts, fibroblasts, fibroblast-like synoviocytes and epithelial cells. High expression of B7-H3 in tumor vasculature also correlates with poor survival in patients, suggesting that it may play a role in tumor cell migration.
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Protein name
CD276 molecule(CD276)
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Protein short names
B7H3; PSEC0249; UNQ309; PRO352
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Uniprot ID
Q5ZPR3
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Human CD276/B7H3/PSEC0249/UNQ309/PRO352 Leu29-Thr461 is expressed with a 6His tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human CD276/B7H3/PSEC0249/UNQ309/PRO352 (His tag) recombinant protein
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