-
Product Name
Canine IL-6R/CD126 (His Tag) recombinant protein
- Documents
-
Description
Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.
-
Protein short names
IL-6R-ALPHA; MGC104991; CD126; IL6RA; IL-6R-1; IL6R; IL-6R
-
Uniprot ID
F1PS25
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the canine IL6R (XP_855105.1) (Met1-Pro365) was expressed with a polyhistidine tag at the C-terminus.
-
Protein Species
Canine
-
Molecular weight
The recombinant canine IL6R consists 357 amino acids and predicts a molecular mass of 39.8 kDa.
-
Purity
> 95 % as determined by SDS-PAGE
-
Validations
Canine IL-6R / CD126 Protein (His Tag)
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"