Rhesus IL6R recombinant protein (C-His)

Rhesus IL6R recombinant protein (C-His)

• DataSheet
• Material Safety Data Sheets (MSDS)

Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy

F6U605

Human Cells

A DNA sequence encoding the rhesus IL6R (XP_001114404.1) (Met1-Pro365) was expressed with a polyhistidine tag at the C-terminus.

Rhesus

The recombinant rhesus IL6R consists of 357 amino acids and predicts a molecular mass of 39.6 kDa.

> 95 % as determined by SDS-PAGE.