Anti-WAP5 / WFDC2 / HE4 antibody

Cat.#: 106131

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Product Information

  • Product Name
    Anti-WAP5 / WFDC2 / HE4 antibody
  • Documents
  • Description
    Rabbit monoclonal to WAP5 / WFDC2 / HE4
  • Tested applications
    IHC-P
  • Species reactivity
    Human WFDC2 / HE4
    No cross-reactivity in ELISA with Rat WFDC2
  • Alternative names
    HE4 antibody; WFDC2 antibody; 1600023A02Rik antibody; dJ461P17.6 antibody; EDDM4 antibody; HE4 antibody; MGC57529 antibody; RP23-140D14.5 antibody; RP3-461P17.2 antibody; WAP5 antibody; WAP5 antibody; Wfdc2 antibody; HE4 antibody; WAP5 antibody; EDDM4 antibody; dJ461P17.6 antibody; HE4 antibody; WAP5 antibody; 1600023A02Rik antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Human WFDC2 / HE4 (rh WFDC2 / HE4; NP_006094.3; Met1-Phe124).
  • Clonality
    Monoclonal
  • Formulation
    0.2 μm filtered solution in PBS with 5% trehalose
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    IHC-P: 1-10 μg/mL

  • Validations

    WAP5 / WFDC2 / HE4 Antibody, Rabbit MAb, Immunohistochemistry

    WAP5 / WFDC2 / HE4 Antibody, Rabbit MAb, Immunohistochemistry

    Immunochemical staining of human WFDC2 in human endometrium with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to the epithelium of uterune gland.

    WAP5 / WFDC2 / HE4 Antibody, Rabbit MAb, Immunohistochemistry

    WAP5 / WFDC2 / HE4 Antibody, Rabbit MAb, Immunohistochemistry

    Immunochemical staining of human WFDC2 in human ovarian cancer (from 7 donors) with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to the malignant cell.

  • Background
    WAP four-disulfide core domain protein 2, also known as Epididymal secretory protein E4, Major epididymis-specific protein E4, Putative protease inhibitor WAP5, WFDC2 and HE4, is a secreted protein which contains two WAP domains. WFDC2 / HE4 is a member of a family of stable 4-disulfide core proteins that are secreted at high levels. It is expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. It is highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis. WFDC2 may be a component of the innate immune defences of the lung, nasal and oral cavities and suggest that WFDC2 functions in concert with related WAP domain containing proteins in epithelial host defence. WFDC2 re-expression in lung carcinomas may prove to be associated with tumour type and should be studied in further detail. Mammary gland expression of tammar WFDC2 during the course of lactation showed WFDC2 was elevated during pregnancy, reduced in early lactation and absent in mid-late lactation. WFDC2 / HE4 can undergo a complex series of alternative splicing events that can potentially yield five distinct WAP domain containing protein isoforms.
  • References
    • Bingle,L. et al., 2002, Oncogene. 21 (17):2768-73.
    • Hellström,I. et al., 2003, Cancer Res. 63 (13):3695-700.
    • Bingle,L. et al., 2006, Respir Res. 7 : 61.
    • Galgano,M.T. et al., 2006, Mod Pathol.19 (6):847-53.
    • Sharp,J.A. et al., 2007, Evol Dev. 9 (4): 378-92.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"