-
Product Name
Anti-IL20RB antibody
- Documents
-
Description
Mouse monoclonal to IL20RB
-
Tested applications
WB
-
Species reactivity
Rat IL20RB
-
Alternative names
AV228068 antibody; DIRS1 antibody; fibronectin type III domain containing 6 antibody; fibronectin type III domain containing 6 antibody; FNDC6 antibody; Fndc6 antibody; Gm186 antibody; hCG_2022374 antibody; IL-20 receptor subunit beta antibody; Il20R2 antibody; IL-20R2 antibody; IL-20RB antibody; IL-20R-beta antibody; interleukin-20 receptor II antibody; interleukin-20 receptor subunit beta antibody; MGC130209 antibody; MGC34923 antibody; DIRS1 antibody; FNDC6 antibody; IL-20R2 antibody; Fndc6 antibody; Gm186 antibody; Il20R2 antibody; AV228068 antibody
- Immunogen
-
Isotype
Mouse IgG1
-
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat IL20RB (rR IL20RB; B8K1X9; Met1-Pro227). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
-
Clonality
Monoclonal
-
Formulation
0.2 μm filtered solution in PBS with 5% treha
-
Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 10-20μg/ml
-
Validations
IL20RB Antibody, Mouse MAb, Western blot
-
Background
IL20RB belongs to the type II cytokine receptor family. There are two kinds of type II cytokine receptors : cytokine receptors that bind type I and type II interferons; cytokine receptors that bind members of the interleukin-10 family (interleukin-10, interleukin-20 and interleukin-22). Type II cytokine receptors are similar to type I cytokine receptors except they do not possess the signature sequence WSXWS that is characteristic of type I receptors. They are expressed on the surface of certain cells, which bind and respond to a select group of cytokines. These receptors are related predominantly by sequence similarities in their extracellular portions that are composed of tandem Ig-like domains. The intracellular domain of type II cytokine receptors is typically associated with a tyrosine kinase belonging to the Janus kinase (JAK) family. IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20.
-
References
- Zhu H, et al. (2009) Expression pattern of mda-7/IL-24 receptors in liver cancer cell lines. Hepatobiliary Pancreat Dis Int. 8(4):402-6.
- Logsdon NJ, et al. (2012) Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun. 68(Pt 1):89-92.
- Kingo K, et al. (2008) Association analysis of IL20RA and IL20RB genes in psoriasis. Genes Immun. 9(5):445-51.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"