Anti-FAK (3D8) Mouse antibody

Cat.#: 168111

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Product Information

  • Product Name
    Anti-FAK (3D8) Mouse antibody
  • Documents
  • Description
    FAK (3D8) Mouse monoclonal antibody
  • Tested applications
    WB, ICC/IF, IP
  • Species reactivity
    Human
  • Alternative names
    FADK 1;FADK;FAK 1;FAK 1;FAK related non kinase polypeptide;FAK1;FAK1_HUMAN;Focal adhesion kinase 1;Focal adhesion kinase 1;Focal adhesion Kinase;Focal adhesion kinase isoform FAK Del33;Focal adhesion kinase related nonkinase;FRNK;p125FAK;pp125FAK;pp125FAK antibody
  • Isotype
    Mouse IgG1
  • Preparation
    Antigen: Purified recombinant human FAK protein fragments expressed in E.coli.
  • Clonality
    Monoclonal
  • Formulation
    PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/1000

    ;ICC: 1/200

  • Validations

    Immunofluorescent analysis of Hela cells fixed fixed by anhydrous methanol at -20u2103 and using FAK mouse mAb (dilution 1:200).

    Immunofluorescent analysis of Hela cells fixed fixed by anhydrous methanol at -20u2103 and using FAK mouse mAb (dilution 1:200).

    Western blot detection of FAK in COS7,HUVEC,A549 and Hela cell lysates using FAK mouse mAb (1:1000 diluted).Predicted band size: 125KDa.Observed band size:125KDa.

    Western blot detection of FAK in COS7,HUVEC,A549 and Hela cell lysates using FAK mouse mAb (1:1000 diluted).Predicted band size: 125KDa.Observed band size:125KDa.

    Immunoprecipitation analysis of Hela cell lysates using FAK mouse mAb.

    Immunoprecipitation analysis of Hela cell lysates using FAK mouse mAb.

  • Background
    Swiss-Prot Acc.Q05397.Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"