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Product Name
Human AIMP1/EMAP II (His Tag) recombinant protein
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Description
Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.
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Protein name
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
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Protein short names
9830137A06RIK; AIMP1; P43; AIMP1/P43; HLD3; EMAP2; EMAPII; SCYE1
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Uniprot ID
Q12904
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Gene Name
AIMP1; EMAP2; SCYE1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the native human SCYE1 (NP_004748.2) (Ala 2-Lys 312) was expressed, with a polyhistide tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human SCYE1 consisting of 318 amino acids and migrates as an 35 kDa band in SDS-PAGE under reducing conditions as predicted.
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Purity
> 97 % as determined by SDS-PAGE
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Validations
Human AIMP1 / EMAP2 / SCYE1 Protein (His Tag) SDS-PAGE
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