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  • alpha-synuclein antibody
  • alpha-synuclein antibody
  • alpha-synuclein antibody
  • alpha-synuclein antibody

alpha-synuclein antibody

Cat.#: 107879

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Product Information

  • Product Name
    alpha-synuclein antibody
  • Documents
  • Description
    alpha-synuclein Rabbit Polyclonal antibody. Positive IF detected in SH-SY5Y cells. Positive IHC detected in human brain tissue, human breast cancer tissue, human kidney tissue, human lung tissue, human placenta tissue, human skin tissue, human testis tissue. Positive WB detected in mouse brain tissue, human brain tissue, SH-SY5Y cells. Observed molecular weight by Western-blot: 15-19kd
  • Tested applications
    ELISA, IHC, WB, IF
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    Alpha synuclein antibody; NACP antibody; PARK1 antibody; PARK4 antibody; PD1 antibody; SNCA antibody
  • Immunogen
  • Isotype
    IgG
  • Preparation
    This antibody was obtained by immunization of alpha-synuclein recombinant protein (Accession Number: BC013293). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

    IF: 1:10-1:100

  • Validations

    mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:107879(SNCA antibody) at dilution of 1:1000

    mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:107879(SNCA antibody) at dilution of 1:1000

    Immunohistochemical of paraffin-embedded human brain using Catalog No:107879(SNCA antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human brain using Catalog No:107879(SNCA antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human brain using Catalog No:107879(SNCA antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemical of paraffin-embedded human brain using Catalog No:107879(SNCA antibody) at dilution of 1:50 (under 40x lens)

    Immunofluorescent analysis of SH-SY5Y cells using Catalog No:107879(a-Synuclein Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

    Immunofluorescent analysis of SH-SY5Y cells using Catalog No:107879(a-Synuclein Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Background
    SNCA, also named as NACP, PARK1 and Alpha-synuclein, belongs to the synuclein family. It may be involved in the regulation of dopamine release and transport. SNCA reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. The deposition of aggregated SNCa is the pathological hallmark of Lewy body disease, which includes Parkinson's disease (PD), diffuse Lewy body disease (DLBD), and Lewy body variant of Alzheimer's disease (LBV).(PMID:21056999) This antibody can recognize all the isoforms of SNCA.
  • References
    • Ying Z, Lin F, Gu W. α-Synuclein increases U251 cells vulnerability to hydrogen peroxide by disrupting calcium homeostasis. Journal of neural transmission (Vienna, Austria : 1996). 118(8):1165-72. 2011.
    • Zhang Y, Ma H, Xie B. Alpha-synuclein overexpression induced mitochondrial damage by the generation of endogenous neurotoxins in PC12 cells. Neuroscience letters. 547:65-9. 2013.
    • Xiong J, Zhang X, Huang J. Fenpropathrin, a Widely Used Pesticide, Causes Dopaminergic Degeneration. Molecular neurobiology. 53(2):995-1008. 2016.
    • Xiang W, Menges S, Schlachetzki JC. Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity. Molecular neurodegeneration. 10:8. 2015.
    • Yang W, Wang G, Wang CE. Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(21):8345-58. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"