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Product Name
Acetyl-Histone H4-K12 pAb
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Description
Polyclonal antibody to Acetyl-Histone H4-K12
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Tested applications
WB, IHC, IF
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Species reactivity
Human, Mouse, Rat, Other (Wide Range)
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Alternative names
HIST1H4B antibody; H4/I antibody; H4FI antibody; histone H4 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic acetylated peptide around K12 of human Histone H4 (NP_001029249.1).
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
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Applications
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200 -
Validations
Immunohistochemistry - Acetyl-Histone H4-K12 pAb
Immunohistochemistry of paraffin-embedded human appendix using Acetyl-Histone H4-K12 antibody at dilution of 1:200 (40x lens).
Immunohistochemistry - Acetyl-Histone H4-K12 pAb
Immunohistochemistry of paraffin-embedded rat ovary using Acetyl-Histone H4-K12 antibody at dilution of 1:200 (40x lens).
Immunohistochemistry - Acetyl-Histone H4-K12 pAb
Immunohistochemistry of paraffin-embedded mouse testis using Acetyl-Histone H4-K12 antibody at dilution of 1:200 (40x lens).
Immunohistochemistry - Acetyl-Histone H4-K12 pAb
Immunohistochemistry of paraffin-embedded mouse spinal cord using Acetyl-Histone H4-K12 antibody at dilution of 1:200 (40x lens).
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Background
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"