ProtLoc is a subcellular localization prediction tool for eukaryotic protein sequences. Users only need to input amino acid sequences to quickly obtain 10-class subcellular localization predictions and confidence scores, suitable for high-throughput annotation, candidate protein screening, and preliminary functional analysis.
1. Protein Sequences (up to 10 FASTA entries):
Parsed sequences: 0, total residues: 0
Output Classes (10)
- Cell membrane
- Cytoplasm
- Endoplasmic reticulum
- Golgi apparatus
- Lysosome/Vacuole
- Mitochondrion
- Nucleus
- Peroxisome
- Plastid
- Extracellular
Scope of Application
- All training data are eukaryotic protein sequences
- Recommended for eukaryotic protein localization studies and annotation tasks
- Interpret results with caution for prokaryotic proteins or datasets with large distribution shifts
Model Performance Metrics
Test metrics | acc=0.8219 balanced_acc=0.6908 mcc=0.7858
precision recall f1-score support
Cell.membrane 0.7429 0.8681 0.8007 273
Cytoplasm 0.7079 0.8158 0.7580 505
Endoplasmic.reticulum 0.6797 0.6012 0.6380 173
Golgi.apparatus 0.7857 0.3143 0.4490 70
Lysosome/Vacuole 0.5405 0.3125 0.3960 64
Mitochondrion 0.8986 0.8510 0.8741 302
Nucleus 0.8950 0.8672 0.8809 806
Peroxisome 0.9286 0.4333 0.5909 30
Plastid 0.9184 0.8882 0.9030 152
Extracellular 0.8931 0.9567 0.9238 393
accuracy 0.8219 2768
macro avg 0.7991 0.6908 0.7215 2768
weighted avg 0.8232 0.8219 0.8167 2768
micro avg 0.8219 0.8219 0.8219 2768
Last updated: 2026-03-25