Recombinant ZC12A protein (His tag)

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Recombinant Human ZC3H12A (Endoribonuclease ZC3H12A/Regnase-1) Fragment (aa 133-343) - A highly purified protein fragment containing the complete RNase NYN domain (aa 135-290), ideal for studying RNA degradation mechanisms, inflammatory response regulation, and immune homeostasis.

Endoribonuclease ZC3H12A, also known as Regnase-1 or MCPIP-1, is a crucial regulator of inflammatory responses and immune homeostasis. This multifunctional protein acts as an endoribonuclease that promotes the decay of specific mRNAs encoding cytokines (such as IL6 and IL12B), cell surface receptors, and transcription factors involved in inflammation and T-cell activation. It plays essential roles in preventing aberrant immune reactions, regulating macrophage polarization, promoting angiogenesis, and controlling microRNA biogenesis through its anti-dicer RNase activity. The protein also functions in deubiquitination processes, affecting NF-kappa-B and JNK signaling pathways. ZC3H12A exhibits antiviral activity against HIV-1 and binds to viral RNAs from Japanese encephalitis and Dengue viruses. Subcellularly, it localizes predominantly to the cytoplasm, including processing bodies (P-bodies), rough endoplasmic reticulum membranes, and cytoplasmic granules, where it interacts with translationally active polysomes and other RNA-binding proteins.