Recombinant ZBT7A protein (His tag)

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Recombinant Human ZBTB7A (1-128) is a high-purity protein fragment encompassing the BTB domain of Zinc finger and BTB domain-containing protein 7A. This fragment serves as an essential tool for investigating the domain-specific mechanisms of ZBTB7A, a key transcription factor involved in gene repression, cell differentiation, and proliferation pathways.

ZBTB7A, also known as FBI-1 or Pokemon, is a multifunctional transcription factor in Homo sapiens that represses genes governing cell proliferation, differentiation, and metabolism. It binds to specific DNA sequences and recruits chromatin modifiers like HDAC1 to suppress transcription, playing critical roles in erythropoiesis, adipogenesis, TGF-beta signaling, and androgen receptor pathways. The full-length protein is nuclear-localized and also participates in DNA repair via non-homologous end joining. The provided fragment (amino acids 1-128) contains the BTB domain, which is central to ZBTB7A's oligomerization and recruitment of corepressor complexes, enabling focused studies on its structural and functional contributions to transcriptional regulation.