YPEL3 Rabbit Polyclonal antibody. Positive WB detected in BxPC-3 cells. Observed molecular weight by Western-blot: 14kd
Human,Mouse,Rat; other species not tested.
Protein yippee like 3 antibody; yippee like 3 (Drosophila) antibody; YPEL3 antibody
This antibody was obtained by immunization of YPEL3 recombinant protein (Accession Number: BC005009). Purification method: Antigen affinity purified.
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20℃. DO NOT ALIQUOT
BxPC-3 cells were subjected to SDS PAGE followed by western blot with Catalog No:116890(YPEL3 antibody) at dilution of 1:1000
YPEL3 is part of a five-member family of closely related paralogues: YPEL1-5, which are named in reference to their Drosophila ortholgue. Studies showed shat YPEL3 is regulated by p53 and its encoding protein induces cellular senescence in human tumor and normal cells, indicating that YPEL3 is a p53-dependent, tumor suppressor gene. (PMID:20388804) 15403-1-AP was raised against full length of YPEL3 protein (1-119aa); it can recognize YPEL1-4.
- Kelley KD, Miller KR, Todd A, Kelley AR, Tuttle R, Berberich SJ. YPEL3, a p53-regulated gene that induces cellular senescence. Cancer research. 70(9):3566-75. 2010.
- Tuttle R, Miller KR, Maiorano JN, Termuhlen PM, Gao Y, Berberich SJ. Novel senescence associated gene, YPEL3, is repressed by estrogen in ER+ mammary tumor cells and required for tamoxifen-induced cellular senescence. International journal of cancer. 130(10):2291-9. 2012.
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