Recombinant YAP1 protein (His tag)

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Recombinant Human YAP1 (Transcriptional coactivator YAP1) Fragment (aa 170-265) is a high-purity protein designed for studying the WW domain-mediated interactions of Yes-associated protein 1. This 96-amino acid fragment contains both WW domains (WW1: 171-204, WW2: 230-263), making it an essential tool for investigating protein-protein interactions in the Hippo signaling pathway and transcriptional regulation mechanisms.

YAP1 is a critical transcriptional regulator in the Hippo signaling pathway, serving dual roles as both a coactivator and corepressor. It functions as a key downstream effector in organ size control and tumor suppression by regulating cell proliferation, apoptosis, and epithelial-mesenchymal transition. YAP1's activity is tightly controlled through phosphorylation-dependent nucleocytoplasmic shuttling, with nuclear localization enabling its interaction with TEAD transcription factors to modulate gene expression. The protein localizes to both cytoplasm and nucleus, with its subcellular distribution influenced by cell density, phosphorylation status, and interactions with regulatory partners. The WW domains contained in this fragment are essential for mediating protein-protein interactions that underlie YAP1's diverse regulatory functions in cellular growth and tissue development pathways.