Recombinant XRCC1 protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Our recombinant protein product features a specific 96-amino acid fragment (residues 538-633) of the human DNA repair protein XRCC1. This fragment is engineered to encompass the BRCT 2 domain, making it an ideal tool for researchers studying domain-specific functions in DNA single-strand break repair and protein interaction mechanisms.

The full-length XRCC1 protein serves as a critical scaffold protein in DNA single-strand break repair by mediating the assembly of DNA break repair complexes. It plays a key regulatory role by negatively modulating the ADP-ribosyltransferase activity of PARP1 during base-excision repair, thereby preventing excessive PARP1 activity through recognition and binding of poly-ADP-ribose chains. XRCC1 is localized primarily in the nucleus and chromosomes, where it translocates from nucleoli to global nuclear chromatin upon DNA damage and is recruited to DNA damage sites via interaction with poly-ADP-ribose chains, highlighting its dynamic role in genomic stability and cellular stress response.