-
Product Name
Recombinant WDR5 protein (His tag)
- Documents
-
Description
Recombinant Human WD repeat-containing protein 5 (WDR5) fragment (residues 2-334) is a high-purity, stable protein designed for structural and biochemical studies. This fragment encompasses the full-length functional domain, offering researchers a soluble and active form ideal for investigating histone modification mechanisms and epigenetic regulation.
WD repeat-containing protein 5 (WDR5) is a nuclear protein crucial for epigenetic regulation through histone modification. It plays a key role in histone H3 lysine-4 methylation and dimethylation as part of the MLL1/MLL complex, promoting transcriptional activation. Additionally, WDR5 contributes to histone H4 acetylation via the NSL complex and supports the methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A, and SETD1B in association with RBBP5 and ASH2L. Its functions are linked to osteoblast differentiation and are localized exclusively in the nucleus, underscoring its importance in chromatin remodeling and gene expression control.
-
Protein name
WD repeat-containing protein 5
-
Uniprot ID
P61964
-
Gene Name
WDR5; BIG3
-
Source/Expression Host
E. coli
-
Expression Plasmid/cDNA
DNA encoding 2-334 aa (P61964) were fused with 6His tag.
-
Protein Species
Human
-
Molecular weight
Predictes a molecular mass of 38.11 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 38 kDa band.
-
Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
-
Activity
Not tested.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"