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Product Name
Recombinant VIPR2 protein (His tag)
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Description
Recombinant Human VIPR2 (Vasoactive intestinal polypeptide receptor 2) Fragment (aa 24-124) is a high-purity protein product designed for structural and biochemical studies. This 101-amino acid fragment, derived from the VPAC2 receptor, represents a stable and soluble unit ideal for investigating receptor function, ligand interactions, and downstream signaling pathways in a simplified model system.
Vasoactive intestinal polypeptide receptor 2 (VIPR2) is a G protein-coupled receptor in humans that responds to neuropeptides including vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP). It exhibits binding specificity with the order of potency PACAP38 = VIP > PACAP27. Upon ligand binding, VIPR2 undergoes conformational changes that activate signaling through G proteins, primarily modulating cAMP-dependent pathways and potentially coupling to phospholipase C. Located in the cell membrane as a multi-pass membrane protein, VIPR2 plays crucial roles in neuroendocrine signaling and cellular communication. The selected fragment (aa 24-124) represents a computationally optimized region that maintains structural integrity while enhancing experimental utility for research applications.
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Protein name
Vasoactive intestinal polypeptide receptor 2
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Uniprot ID
P41587
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Gene Name
VIPR2; VIP2R
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 24-124 aa (P41587) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 13.12 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 14 kDa band.
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Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"