VDR antibody

VDR antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

VDR Rabbit Polyclonal antibody. Positive WB detected in PC-3 cells. Observed molecular weight by Western-blot: 55 kDa

ELISA, WB

Human,Mouse,Rat; other species not tested.

NR1I1 antibody; VDR antibody; Vitamin D3 receptor antibody

Rabbit IgG

This antibody was obtained by immunization of VDR recombinant protein (Accession Number: XM_047429500). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

The vitamin D receptor (VDR), also known as the calcitriol receptor, and also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factors. Upon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or trans-repression of specific gene products.It is an intracellular hormone receptor that specifically binds 1,25(OH)2D3 and mediates its effects. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A). A disorder of vitamin D metabolism results in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets. This antibody is a rabbit polyclonal antibody to human VDR.