Recombinant VASP protein (His tag)

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Recombinant Human Vasodilator-stimulated phosphoprotein (VASP) fragment (residues 2-116) is a high-purity protein designed for studying actin cytoskeleton dynamics. This fragment fully encompasses the WH1 domain, making it an ideal tool for investigating domain-specific functions in processes such as cell migration, platelet activation, and pathogen motility.

Vasodilator-stimulated phosphoprotein (VASP) is a key actin-associated protein involved in cytoskeleton remodeling and cell polarity. It promotes actin filament elongation by protecting barbed ends from capping and facilitates the transfer of profilin-bound actin monomers to growing filaments. VASP regulates critical cellular processes including axon guidance, lamellipodial and filopodial dynamics, platelet aggregation, and cell migration. It also supports actin-based mobility of pathogens like Listeria monocytogenes. Subcellularly, VASP localizes to the cytoplasm, cytoskeleton, focal adhesions, tight junctions, and membrane projections such as lamellipodia and filopodia tips, where it dynamically associates with stress fibers and membrane protrusions.