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Product Name
Human BPHL (His Tag) recombinant protein
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Description
Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol.
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Protein name
Valacyclovir hydrolase
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Protein short names
BPH-RP; BIPHENYL HYDROLASE-LIKE (SERINE HYDROLASE); BIPHENYL HYDROLASE-LIKE PROTEIN; VALACYCLOVIRASE; 2010012D11RIK; BREAST EPITHELIAL MUCIN-ASSOCIATED ANTIGEN; BIPHENYL HYDROLASE-LIKE (SERINE HYDROLASE; 5730533B08RIK; VALACYCLOVIR HYDROLASE; BPHL; VACVASE; AI115341; BREAST EPITHELIAL MUCIN-ASSOCIATED ANTIGEN); BIPHENYL HYDROLASE-RELATED PROTEIN; MCNAA
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Uniprot ID
Q86WA6
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Gene Name
BPHL; MCNAA
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human BPHL (Q86WA6-1) (Ser38-Gln291) was expressed with a polyhistide tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human BPHL consists of 268 amino acids and predicts a molecular mass of 30.7 KDa. It migrates as an approximately 31 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human BPHL Protein (His Tag) SDS-PAGE
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