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Product Name
Recombinant UPP1 protein (His tag)
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Description
Recombinant Human Uridine phosphorylase 1 (UPase 1) Fragment (residues 1-310) is a high-purity protein designed for structural and biochemical studies. This fragment represents a stable and soluble unit of the enzyme, ideal for investigating its role in pyrimidine metabolism and nucleotide synthesis.
Uridine phosphorylase 1 (UPase 1), encoded by the UPP1 gene in Homo sapiens, catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate. This reaction is essential for utilizing uridine as a carbon and energy source and for rescuing pyrimidine bases to support nucleotide synthesis. The enzyme exhibits broad substrate specificity, also accepting deoxyuridine and analogous compounds, highlighting its versatility in pyrimidine metabolism. The fragment (residues 1-310) was selected computationally to ensure stability and solubility, facilitating research into its catalytic mechanisms and biological functions.
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Protein name
Uridine phosphorylase 1
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Uniprot ID
Q16831
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Gene Name
UPP1; UP
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-310 aa (Q16831) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 35.59 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 36 kDa band.
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Purity
>88%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"