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Recombinant UGDH protein (His tag)

Recombinant UGDH protein (His tag)

Cat.#: 539520

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Special Price 294.7 USD

Availability: 3-4 weeks
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Product Information

  • Product Name
    Recombinant UGDH protein (His tag)
  • Documents
  • Description

    This product is a recombinant fragment of Human UDP-glucose 6-dehydrogenase (UDP-GlcDH, UGDH, EC 1.1.1.22), encompassing residues 1-494. It is designed for structural and biochemical studies, offering a stable and soluble unit that facilitates research into glycosaminoglycan biosynthesis and related pathways.

    UDP-glucose 6-dehydrogenase (UDP-GlcDH) is a key enzyme in human metabolism, catalyzing the conversion of UDP-alpha-D-glucose to UDP-alpha-D-glucuronate. This reaction is essential for the biosynthesis of complex glycosaminoglycans, including chondroitin sulfate and heparan sulfate, which are critical components of the extracellular matrix. The enzyme plays a vital role in embryonic development, brain formation, and neuronal function, as supported by multiple studies (e.g., PubMed:21502315, PubMed:32001716). Its activity is fundamental to cellular processes involving glycosylation and tissue integrity.

  • Protein name
    UDP-glucose 6-dehydrogenase
  • Uniprot ID
    O60701
  • Gene Name
    UGDH
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 1-494 aa (O60701) were fused with 6His tag.
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 56.68 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 58 kDa band.
  • Purity
    >90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"