Recombinant UFO protein (His tag)

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Recombinant Human AXL (Tyrosine-protein kinase receptor UFO) Fragment (aa 34-451) - a high-purity protein encompassing key extracellular domains (Ig-like C2-type 2 and Fibronectin type-III 1/2), ideal for studying receptor-ligand interactions, signal transduction mechanisms, and viral entry pathways in cancer and immunology research.

AXL is a receptor tyrosine kinase that binds growth factor GAS6, regulating critical cellular processes including survival, proliferation, migration, and differentiation. Upon ligand-induced activation, AXL initiates multiple signaling pathways through phosphorylation of PI3-kinase subunits, GRB2, PLCG1, and other substrates, ultimately activating AKT kinase. This receptor plays significant roles in endothelial cell survival, platelet activation, thrombotic responses, and suppression of Toll-like receptor-mediated innate immunity. Notably, AXL serves as an entry receptor for multiple viruses including Lassa virus, lymphocytic choriomeningitis virus, Ebolavirus, and Zika virus, where it facilitates viral entry and modulates interferon signaling. The full-length protein is localized to the cell membrane as a single-pass type I membrane protein, positioning it optimally for both extracellular ligand binding and intracellular signal transduction.