Recombinant UD16 protein (His tag)

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Recombinant Human UDP-glucuronosyltransferase 1A6 (UGT1A6) Fragment (residues 27-489) is a high-purity protein designed for structural and biochemical studies. This 463-amino acid fragment retains key functional regions, offering a stable and soluble unit ideal for investigating phase II biotransformation and detoxification pathways.

UDP-glucuronosyltransferase 1A6 (UGT1A6) is a critical enzyme in phase II biotransformation, catalyzing the conjugation of lipophilic substrates with glucuronic acid to facilitate their detoxification and excretion. It plays an essential role in metabolizing drugs, xenobiotics, and endogenous compounds, including arachidonic acid and its derivatives like 15-HETE and 20-HETE. UGT1A6 is also involved in glucuronidating small planar phenolic molecules such as 4-nitrophenol and ferulic acid, but not bulky phenols like 4-hydroxybiphenyl. Isoform 1 is the active form, while isoform 3 acts as a negative regulator. The enzyme is localized to the endoplasmic reticulum membrane as a single-pass membrane protein, underscoring its role in microsomal metabolic processes.