Recombinant UBX2A protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Recombinant UBX domain-containing protein 2A (UBXN2A) fragment (residues 39-259) from Homo sapiens, encompassing the full SEP and UBX functional domains. This high-purity protein is an essential tool for investigating domain-specific mechanisms in ubiquitin-related processes, endoplasmic reticulum-associated degradation, and mTORC2 pathway regulation, offering researchers a targeted reagent for functional and interaction studies.

UBX domain-containing protein 2A (UBXN2A) is a multifunctional human protein involved in key cellular processes, including the regulation of ubiquitination and protein degradation. It acts to repress endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons, promoting its translocation to the plasma membrane and enhancing acetylcholine-gated ion-channel activity. Additionally, UBXN2A inhibits STUB1-mediated degradation of TP53 and positively mediates ubiquitination and degradation of RICTOR, thereby acting as a negative regulator of the mTORC2 signaling pathway. The protein localizes to multiple cellular compartments, including the Golgi apparatus, endoplasmic reticulum, perikaryon, dendrites, nucleus, and cytoplasm, with specific expression at the axon initial segment, highlighting its diverse roles in neuronal and general cellular function.