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Product Name
Recombinant UBR1 protein (His tag)
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Description
Recombinant E3 ubiquitin-protein ligase ubr-1 fragment (residues 1-350) from Caenorhabditis elegans, a stable and soluble unit ideal for structural and biochemical investigations into N-end rule pathway regulation and protein degradation mechanisms.
The full-length E3 ubiquitin-protein ligase ubr-1 is a RING-type E3 ubiquitin transferase that functions as a key component of the N-end rule pathway. It recognizes proteins with specific destabilizing N-terminal residues, facilitating their ubiquitination and subsequent proteasomal degradation. This enzyme plays critical roles in developmental processes, such as regulating seam cell patterning through the degradation of the heterochronic protein lin-28 in collaboration with ced-3, and modulates glutamate metabolism via the aspartate aminotransferase got-1.2 to influence locomotory behavior. As a single-pass membrane protein localized to the membrane, ubr-1 is integral to cellular protein quality control and signaling pathways.
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Protein name
E3 ubiquitin-protein ligase ubr-1
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Uniprot ID
P91133
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Gene Name
ubr-1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-350 aa (P91133) were fused with 6His tag.
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Sequence
1-350
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Protein Species
Caenorhabditis elegans
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Molecular weight
Predictes a molecular mass of 40.87 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 43 kDa band.
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Purity
>87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"