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Product Name
Recombinant TX101 protein (His tag)
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Description
Recombinant Human TEX101 Protein Fragment (aa 26-211) - A high-purity research tool containing the complete UPAR/Ly6 functional domain, ideal for investigating sperm function, fertilization mechanisms, and signal transduction pathways.
Testis-expressed protein 101 (TEX101) plays a crucial role in fertilization by controlling sperm binding to the zona pellucida and regulating spermatozoa migration into the oviduct. The protein is implicated in signal transduction processes and promotes protein tyrosine phosphorylation. TEX101 localizes to multiple cellular compartments including the cell membrane (via GPI-anchor), membrane rafts, cytoplasmic vesicles, secretory vesicles, acrosome structures, and is also secreted. It is specifically expressed on the plasma membrane of spermatocytes, round and elongated spermatids, and testicular spermatozoa, highlighting its importance in male reproductive biology and potential relevance to autoimmune conditions such as scleroderma.
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Protein name
Testis-expressed protein 101
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Uniprot ID
Q9BY14
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Gene Name
TEX101; SGRG
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 26-211 aa (Q9BY14) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 21.45 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 21 kDa band.
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Purity
>87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"