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Product Name
Human TNFRSF25/DR3/TNFRSF12 (Fc Tag) recombinant protein
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Description
Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
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Protein name
Tumor necrosis factor receptor superfamily member 25
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Protein short names
WSL-1; LARD; WSL-LR; DR3; WSL; TRAMP; TNFRSF12; RP4-650H14.2; APO-3; DDR3; TR3; TNFRSF25; RP23-284C20.2
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Uniprot ID
Q93038
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Gene Name
TNFRSF25; APO3; DDR3; DR3; TNFRSF12; WSL; WSL1; UNQ455/PRO779
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human TNFRSF25 (NP_003781.1) extracellular domain (Met 1-Gln 199) was fused with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human TNFRSF25/Fc is a disulfide-linked homodimer. The reduced monomer consists of 416 amino acids and has a predicted molecular mass of 46 kDa. As a result of glycosylation, rhTNFRSF25/Fc monomer migrates as an approximately 55 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 96 % as determined by SDS-PAGE
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Validations
Human TNFRSF25 / DR3 / TNFRSF12 Protein (Fc Tag) SDS-PAGE
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