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Product Name
Recombinant TTPA protein (His tag)
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Description
Recombinant Alpha-tocopherol transfer protein (Alpha-TTP) fragment (residues 1-278) from Homo sapiens, encompassing the full CRAL-TRIO functional domain. This high-purity protein is ideal for investigating alpha-tocopherol binding, transfer mechanisms, and lipid signaling interactions in vitro.
Alpha-tocopherol transfer protein (Alpha-TTP), encoded by the TTPA gene, plays a critical role in vitamin E metabolism by specifically binding alpha-tocopherol and facilitating its transfer between membranes. It enhances the release of alpha-tocopherol from liver cells and interacts with phosphoinositides like phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate, inducing conformational changes essential for tocopherol release. Located in the cytoplasm, Alpha-TTP is vital for cellular antioxidant defense and lipid homeostasis, with mutations linked to vitamin E deficiency disorders.
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Protein name
Alpha-tocopherol transfer protein
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Uniprot ID
P49638
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Gene Name
TTPA; TPP1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-278 aa (P49638) were fused with 6His tag.
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Sequence
1-278
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 33.41 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 33 kDa band.
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Purity
>86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"