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Product Name
Recombinant TRPV5 protein (His tag)
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Description
Recombinant Human TRPV5 Protein Fragment (1-327) is a high-quality, soluble protein fragment derived from the Transient Receptor Potential Cation Channel Subfamily V Member 5 (TrpV5). This fragment is engineered for structural and biochemical studies, providing researchers with a stable and functional unit ideal for investigating calcium channel mechanisms and related pathways.
TRPV5 is a constitutively active, calcium-selective cation channel primarily involved in calcium reabsorption in the kidney and intestine. It plays a critical role in maintaining calcium homeostasis by facilitating Ca²⁺ uptake in distal convoluted tubules of the kidney. The channel is activated by low internal calcium levels and exhibits inward rectification, with regulation through Ca²⁺-dependent feedback mechanisms including fast inactivation and slow current decay. TRPV5 can form heteromeric complexes with TRPV6, which modulates its channel properties. Located in the apical cell membrane of kidney distal tubular cells, TRPV5's expression and membrane localization are influenced by interactions with proteins such as S100A10, annexin A2, and WNK3, highlighting its importance in epithelial calcium transport and potential implications in renal and metabolic disorders.
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Protein name
Transient receptor potential cation channel subfamily V member 5
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Uniprot ID
Q9NQA5
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Gene Name
TRPV5; ECAC1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-327 aa (Q9NQA5) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 38.45 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 38 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"