-
Product Name
TRIB3 Polyclonal Antibody
- Documents
-
Description
Polyclonal antibody to TRIB3
-
Tested applications
WB
-
Species reactivity
Human, Mouse
-
Alternative names
TRIB3 antibody; C20orf97 antibody; NIPK antibody; SINK antibody; SKIP3 antibody; TRB3 antibody; tribbles homolog 3 antibody
-
Isotype
Rabbit IgG
-
Preparation
Antigen: A synthetic peptide of human TRIB3
-
Clonality
Polyclonal
-
Formulation
PBS with 0.02% sodium azide, pH7.3.
-
Storage instructions
Store at 4℃. Avoid freeze / thaw cycles.
-
Applications
WB 1:500 - 1:1000
-
Validations
Western blot - TRIB3 Polyclonal Antibody
Western blot analysis of extracts of mouse liver, using TRIB3 antibody .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.
-
Background
Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"