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Recombinant TRI47 protein (His tag)

Recombinant TRI47 protein (His tag)

Cat.#: 538739

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Product Information

  • Product Name
    Recombinant TRI47 protein (His tag)
  • Documents
  • Description

    This recombinant protein is a 261-amino acid fragment (residues 125-385) of human E3 ubiquitin-protein ligase TRIM47. It has been computationally selected for stability and solubility, making it ideal for structural studies, biochemical assays, and functional investigations into ubiquitination pathways.

    TRIM47 is an E3 ubiquitin-protein ligase that plays a critical role in the ubiquitin-proteasome system by mediating the ubiquitination and subsequent proteasomal degradation of CYLD, a key regulator of inflammatory signaling and cell survival pathways. The full-length protein is localized in both the cytoplasm and nucleus, indicating its involvement in diverse cellular processes. Dysregulation of TRIM47 has been implicated in disease contexts, underscoring its importance as a research target for understanding protein homeostasis and signaling mechanisms.

  • Protein name
    E3 ubiquitin-protein ligase TRIM47
  • Uniprot ID
    Q96LD4
  • Gene Name
    TRIM47; GOA; RNF100
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 125-385 aa (Q96LD4) were fused with 6His tag.
  • Sequence 
    125-385
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 30.34 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 32 kDa band.
  • Purity
    >90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"