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Product Name
Recombinant TRI29 protein (His tag)
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Description
Introducing the recombinant human TRIM29 protein fragment (residues 170-430), a stable and soluble unit derived from Tripartite motif-containing protein 29. This fragment is ideal for investigating the protein's role in modulating immune responses, particularly in respiratory infections, through structural and biochemical studies.
TRIM29, also known as Ataxia telangiectasia group D-associated protein, is a key regulator of macrophage activation during viral or bacterial infections in the respiratory tract. It functions by interacting with IKBKG/NEMO and STING1 in the lysosome, promoting their 'Lys-48' ubiquitination and degradation. This process suppresses the expression of type I interferons and pro-inflammatory cytokines, highlighting its critical role in immune modulation. The protein localizes to the cytoplasm and lysosome, where it colocalizes with intermediate filaments, underscoring its involvement in cellular signaling pathways.
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Protein name
Tripartite motif-containing protein 29
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Uniprot ID
Q14134
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Gene Name
TRIM29; ATDC
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 170-430 aa (Q14134) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 31.78 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 36 kDa band.
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Purity
>86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"