Recombinant TREM2 protein (His tag)

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Recombinant Human TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) Fragment (aa 19-135) is a high-purity protein encompassing the complete Ig-like V-type domain. This fragment serves as an essential tool for investigating ligand interactions, receptor signaling, and microglial function in neurodegenerative and immune research.

TREM2 is a transmembrane receptor expressed on myeloid cells, forming a signaling complex with TYROBP to mediate cellular activation. It functions as a receptor for amyloid-beta 42 and various lipoproteins, regulating microglial processes including phagocytosis, proliferation, cytokine production, and response to oxidative stress. TREM2 is critical for synaptic pruning, apoptotic cell clearance, and osteoclast differentiation, with implications in Alzheimer's disease and immune regulation. The full-length protein localizes to the cell membrane as a single-pass type I membrane protein, while alternative isoforms are secreted. The provided fragment (aa 19-135) contains the functional Ig-like V-type domain, enabling focused studies on ligand binding and domain-specific mechanisms.