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Product Name
Rat TGF-beta 1/TGFB1 (His Tag) recombinant protein
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Description
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells (By similarity).
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Protein name
Transforming growth factor beta-1
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Protein short names
TGFBETA; TGFB1; LAP; TGFB-1; TGFB; TGF-BETA 1; CED; DPD1; TGF-BETA1; TGFBETA1
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Uniprot ID
P17246
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Gene Name
Tgfb1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat Latent TGFB1 (P17246) (Met1-Ser390) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat Latent TGFB1 comprises 372 amino acids and predicts a molecular mass of 42.7 kDa. The apparent molecular mass of the recombinant protein is approximately 55, 38 and 16 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Rat Latent TGF-beta 1 / TGFB1 Protein (His Tag) SDS-PAGE
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