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Recombinant TPM3 protein (His tag)

Recombinant TPM3 protein (His tag)

Cat.#: 544320

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Product Information

  • Product Name
    Recombinant TPM3 protein (His tag)
  • Documents
  • Description

    Recombinant Tropomyosin alpha-3 chain (TPM3) fragment (residues 2-285) from Homo sapiens, engineered for stability and solubility to facilitate structural and biochemical studies of actin-binding and muscle regulation mechanisms.

    Tropomyosin alpha-3 chain, encoded by the TPM3 gene, binds to actin filaments in both muscle and non-muscle cells. It plays a central role in calcium-dependent regulation of vertebrate striated muscle contraction through association with the troponin complex, while in smooth muscle, it interacts with caldesmon to modulate contraction. In non-muscle cells, it contributes to cytoskeletal stability by reinforcing actin filaments. This protein is localized to the cytoplasm and cytoskeleton, underscoring its fundamental role in cellular structure and contractile processes.

  • Protein name
    Tropomyosin alpha-3 chain
  • Uniprot ID
    P06753
  • Gene Name
    TPM3
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 2-285 aa (P06753) were fused with 6His tag.
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 34.48 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 47 kDa band.
  • Purity
    >85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"