Recombinant TMM59 protein (His tag)

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Recombinant Human Transmembrane protein 59 (TMEM59) fragment (residues 44-182) is a stable, soluble protein unit designed for structural and biochemical studies. This fragment enables researchers to investigate the autophagy-regulating and glycosylation-modulating functions of TMEM59 in a manageable format, supporting research on cellular responses to infection and protein processing pathways.

Transmembrane protein 59 (TMEM59) is a human single-pass type I membrane protein primarily localized to late endosomes, lysosomes, the cell membrane, and the Golgi apparatus. It functions as a key regulator of autophagy during Staphylococcus aureus infection by interacting with ATG16L1 to promote LC3 lipidation and activation, facilitating bacterial clearance. Additionally, TMEM59 modulates O-glycosylation and complex N-glycosylation of proteins such as APP, BACE1, SEAP, and PRNP during Golgi maturation, and inhibits APP transport to the cell surface and subsequent shedding. These roles highlight its importance in cellular defense mechanisms and protein processing, making it a significant target for studies in autophagy, infectious diseases, and neurodegenerative pathways.