Recombinant TMED1 protein (His tag)

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Recombinant Human TMED1 Fragment (aa 24-194) is a high-purity protein designed for studying vesicular trafficking and immune signaling pathways. This fragment encompasses the full GOLD domain (aa 43-125), making it an ideal tool for investigating domain-specific interactions in interleukin-33 receptor binding and cGAS-STING pathway modulation.

Transmembrane emp24 domain-containing protein 1 (TMED1) plays a critical role in vesicular protein trafficking within the early secretory pathway, functioning as a cargo receptor for transport vesicle formation. It localizes to the endoplasmic reticulum membrane, Golgi apparatus, and endoplasmic reticulum-Golgi intermediate compartment as a single-pass type I membrane protein. TMED1 enhances IL-33-mediated IL-8 and IL-6 production through interaction with interleukin-33 receptor IL1RL1 and modulates innate immune signaling via the cGAS-STING pathway through RNF26 interaction, positioning it as a key regulator of intracellular transport and immune response mechanisms.