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Product Name
Recombinant TLR3 protein (His tag)
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Description
Recombinant Human Toll-like Receptor 3 (CD283) Fragment (aa 726-904) is a high-purity protein designed for studying the TIR domain's role in innate immune signaling. This fragment enables targeted investigation of dsRNA-mediated viral recognition pathways and downstream immune activation.
Toll-like receptor 3 (TLR3) is a crucial component of both innate and adaptive immunity, functioning as a pattern recognition receptor that detects double-stranded RNA—a hallmark of viral infection. Located primarily in endoplasmic reticulum and endosomal membranes, TLR3 initiates immune responses through TRIF/TICAM1 adapter protein signaling, leading to NF-κB activation, IRF3 nuclear translocation, and inflammatory cytokine production. This positions TLR3 as a key mediator in antiviral defense mechanisms and inflammatory regulation.
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Protein name
Toll-like receptor 3
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Uniprot ID
O15455
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Gene Name
TLR3
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 726-904 aa (O15455) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 23.01 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 24 kDa band.
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Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"