Recombinant TLK1 protein (His tag)

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Recombinant Human Serine/threonine-protein kinase tousled-like 1 (TLK1) fragment (amino acids 390-766) is a high-purity protein encompassing the complete protein kinase domain. This fragment serves as an essential tool for investigating kinase activity, DNA damage response mechanisms, and chromatin regulation in life science research.

The full-length Serine/threonine-protein kinase tousled-like 1 (TLK1) is a human nuclear kinase that plays critical roles in cell cycle regulation and DNA damage response. It undergoes rapid, transient inhibition following DNA double-stranded breaks during S-phase through a cell cycle checkpoint and ATM-pathway dependent mechanism, regulating processes involved in chromatin assembly. TLK1 phosphorylates histone H3 at 'Ser-10' in vitro and has been shown to protect cells from ionizing radiation by facilitating the repair of double-strand breaks. Additionally, specific isoforms enhance the stability of t-SNARE SNAP23, augmenting its assembly with syntaxin. The protein's nuclear localization underscores its importance in DNA-related processes and chromatin dynamics.