Recombinant TLE1 protein (His tag)

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Recombinant Human TLE1 Protein Fragment (443-770) is a highly stable and soluble unit of the Transducin-like enhancer protein 1, designed for structural and biochemical studies. This fragment, derived from the Homo sapiens TLE1 gene, facilitates research into transcriptional corepressor mechanisms and signaling pathways.

Transducin-like enhancer protein 1 (TLE1) is a transcriptional corepressor in humans that binds to various transcription factors, inhibiting NF-kappa-B-regulated gene expression and modulating Wnt signaling by repressing CTNNB1 and TCF family members. It also enhances repression mediated by FOXG1/BF-1 and HES1, while uniquely acting as a coactivator for ESRRG. TLE1 is primarily localized in the nucleus, with its affinity for nuclear components regulated by phosphorylation-dependent hyperphosphorylation, influencing its chromatin association. This fragment (residues 443-770) represents a computationally optimized region for experimental applications, supporting investigations into its regulatory roles without contained domains.