Recombinant TIE2 protein (His tag)

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Recombinant Human Angiopoietin-1 Receptor (TEK) Fragment (residues 815-1124) – a high-purity protein kinase domain designed for studying angiogenesis, endothelial signaling, and kinase activity. This fragment provides a targeted tool for investigating TEK's role in vascular biology and receptor tyrosine kinase function.

Angiopoietin-1 receptor (TEK/TIE-2) is a crucial endothelial tyrosine kinase that regulates angiogenesis, endothelial cell survival, migration, and vascular stability. As a receptor for ANGPT1, ANGPT2, and ANGPT4, it controls multiple signaling pathways including PI3K/AKT and MAPK cascades, maintaining vascular quiescence while modulating inflammatory responses. The full-length protein localizes to the cell membrane, cell junctions, and focal adhesions, with proteolytic processing generating a soluble extracellular domain. This recombinant fragment containing the complete protein kinase domain (residues 824-1096) enables focused investigation of TEK's catalytic activity and downstream signaling mechanisms in vascular development and disease contexts.