Mouse THOP1 (His Tag) recombinant protein

Cat.#: 502102

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Product Information

  • Product Name
    Mouse THOP1 (His Tag) recombinant protein
  • Documents
  • Description
    Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments (By similarity).
  • Protein name
    Thimet oligopeptidase
  • Protein short names
    THOP1; AI327041; MP78; MEPD_HUMAN; AI131655; EP24.15; TOP
  • Uniprot ID
    Q8C1A5
  • Gene Name
    Thop1
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse THOP1 (NP_073144.3) (Lys 2-Cys 687) was fused with a polyhistidine tag at the N-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse THOP1 consists of 705 amino acids and has a calculated molecular mass of 80.1 kDa. It migrates as an approximately 75 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to cleave a fluorogenic peptide substrate, (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Pro-D-Lys(2,4-dinitrophenyl)-OH or Mca-PLGPK(Dnp)-OH.
    The specific activity is > 500 pmoles/min/μg.
  • Validations

    Mouse THOP1 Protein (His Tag) SDS-PAGE

    Mouse THOP1 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"